A proficient data and brilliant forecasting techniques used in this Alagille Syndrome Market report are synonymous with accurateness and correctness. The document is a meticulous analysis of existing scenario of the market, which covers several market dynamics. This market research report endows with the plentiful insights and business solutions that will support to stay ahead of the competition. The most precise way to forecast what future holds is to understand the trend today and hence Alagille Syndrome Marketing report has been structured by chewing over numerous fragments of the present and upcoming market scenario.
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This Alagille Syndrome Market report is the consequence of incessant efforts lead by clued-up forecasters, innovative analysts and bright researchers who indulge in detailed and attentive research on different markets, trends and emerging opportunities in the consecutive direction for the business needs. Company snapshot, geographical presence, product portfolio, and recent developments are taken into account for studying the company profiles that are part of this report. Quality and transparency has been strictly maintained while carrying out research studies to offer an exceptional market research report for a niche. A thoughtful knowledge of industrial unanimity, market trends and incredible techniques via this Alagille Syndrome Market report gives an upper hand in the market.
Global Alagille syndrome market is expected to grow at a substantial CAGR in the forecast period of 2019-2026. Presence of refined healthcare infrastructure and increase in special designation from the regulatory authorities are the key factors that drive the market.
Few of the major competitors currently working in the global Alagille syndrome market are Albireo Pharma, Inc, Mirum Pharmaceuticals, Teva Pharmaceutical Industries Ltd, Zydus Cadila, ALLERGAN, Endo Pharmaceuticals Inc, ANI Pharmaceuticals, Inc, Mylan N.V., Glenmark Pharmaceuticals Ltd, Amneal Pharmaceuticals LLC, Epic Pharma, LLC, Lannett, Fresenius Kabi AG, Lannett, Novartis AG, Pfizer, Inc, Lupin, Hikma Pharmaceuticals PLC, Akorn, Incorporated and others.
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Market Definition: Global Alagille Syndrome Market
Alagille syndrome is a rare autosomal dominant genetic disorder that affects multiple organ system of the body most commonly in the liver, heart, skeleton, eyes and kidneys. It is associated with liver diseases, hepatomegaly, and biliary atresia and in severe cases liver transplantation may be necessary. Alagille syndrome is caused by either mutation in the JAG1 gene or deletion in genetic material on chromosome 20 that include the JAG1 gene. These proteins is necessary for Notch signaling between neighboring cells during embryonic development and error in genes results in abnormalities in the bile ducts, heart, spinal column, and certain facial features
According to the statistics published in the U.S. Department of Health & Human Services, an estimated annual prevalence of Alagille syndrome worldwide is 1 in 70,000 newborns. Introduction of the drugs used to treat complication associated with Alagille syndrome and presence of refined healthcare infrastructure is fueling the growth of this market
Segmentation: Global Alagille Syndrome Market
Alagille Syndrome Market : By Treatment
Alagille Syndrome Market : By Drugs
- Ursodeoxycholic Acid
Alagille Syndrome Market : By Route of Administration
Alagille Syndrome Market : By Diagnosis
- Blood Test
Alagille Syndrome Market : By End Users
- Specialty Clinics
Alagille Syndrome Market : By Distribution Channel
- Hospital Pharmacies
- Retail Pharmacies
Alagille Syndrome Market : By Geography
- North America
- South America
- Middle East & Africa
Key Developments in the Alagille Syndrome Market:
- In April 2019, Mirum Pharmaceuticals presented a phase II ICONIC clinical trial study data at The International Liver Congress 2019 for maralixibat for the treatment of Alagille syndrome. The trial has demonstrated the well tolerated dose with no serious adverse events as well as durable improvements in itch severity and serum bile acids in children with Alagille syndrome. If trial successful, it could became first approved treatment for patients suffering from Alagille syndrome.
- In October 2018, Albireo Pharma, Inc received an Orphan Drug designation from the FDA for A4250, an ileal bile acid transporter (IBAT) inhibitor for the treatment of Alagille syndrome. A4250 also hold the PRIority MEdicines (PRIME) designation and Orphan Drug designation from both the FDA and EMA for the treatment of progressive intrahepatic cholestasis (PFIC). With this designation, company can obtain regulatory and financial incentives for development along with 7 year market exclusivity.
Alagille Syndrome Market Drivers :
- Increase in special designation from the regulatory authorities is drive the market
- Growing prevalence of cancer has boosted the development of the novel treatments can enhance the market growth
- Rise in number of patients suffering from paragangliomas and continuous advances in the treatment is propelling the market growth
- Huge financial support to the researchers for developing novel intervention is boosting the market growth
Alagille Syndrome Market Restraints :
- Rise in cases of product recalls are expect to cause a shortfall in the market
- Limited operating revenue opportunities for research and development of targeted therapies by many pharmaceuticals is acting as a challenging factor for the growth of this market
- Lack of healthcare budget in some middle-income countries is restraining the market growth
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